To obtain structural information about the interaction mode of these inhibitors in the active site of the enzymes, we have solved serveral complexes of the enzymes and the inhibitors developed in the group in collaboration with Dr. Mark J. van Raaij from the National Centre of Biotechnology in Madrid. Some of these crystal structures are shown here.
Crystal Structures List:
(a) Type II Dehydroquinase from Mycobacterium tuberculosis (Mt-DHQ2)
(b) Type II Dehydroquinase from Helicobacter pylori (Hp-DHQ2)
(c) Type I Dehydroquinase from Salmonella typhi (St-DHQ1)
(d) Type I Dehydroquinase from Staphylococcus aureus (Sa-DHQ1)
(e) Shikimate kinase from Mycobacterium tuberculosis (Mt-SK)