2022

M. Panciera, E. Lence, A. Rodríguez, B. Gracia, J. A. Aínsa, C. Marco-Marín, V. Rubio, C. R. D. Correia, and C. González-Bello*

Discovery of 3H-pyrrolo[2,3-c]quinolines with Activity Against Mycobacterium tuberculosis by Allosteric Inhibition of the Glutamate-5-Kinase Enzyme

Eur. J. Med. Chem.  2022, 232, 114206 (link)

 

Alba Ruedas-López, Isaac Alonso-Garcia, Cristina Monterrubio, Paula Guijarro-Sánchez, Eva Gato, Juan Vázquez-Ucha, Juan Vallejo, Pablo Fraile-Ribot, Begoña Fernández, David Velasco, Jose Gutiérrez-Urbón, Marina Oviaño, Alejandro Beceiro, Concepción Gonzalez-Bello, Antonio Oliver, Jorge Arca-Suárez, and Germán Bou

Selection of AmpC β-lactamase Variants and Metallo-β-lactamases Leading to Ceftolozane/Tazobactam and Ceftazidime/Avibactam-resistance During Treatment of MDR/XDR Pseudomonas aeruginosa Infections

Antimicrob. Agents Chemother. 2022, 66,  e02067-21 (10.1128/AAC.02067-21)

 

2021

E. Lence, and C. González-Bello*

Molecular Basis of Bicyclic Boronate β-Lactamase Inhibitors of Ultrabroad Efficacy ─ Insights from Molecular Dynamics Simulation Studies

Front. Microbiol. 2021, 12, 721826  (doi: 10.3389/fmicb.2021.721826)

 

J. A Rubiolo, E. Lence, C. González-Bello, M. Roel, J. Gil-Longo, M. Campos-Toimil, E. Ternon, O. P. Thomas, A. Cantalapiedra, H. López-Alonso, M. Rodriguez Vieytes, and L. M. Botana

Crambescin C1 as a possible substrate candidate of iNOS and eNOS increasing nitric oxide production with an in vivo hypotensive effect

Front. Pharmacol. 2021, 12, 694639 ( doi: 10.3389/fphar.2021.694639)

 

J. C. Vázquez-Ucha, D. Rodríguez, C. Lasarte-Monterrubio, E. Lence, J. Arca-Suarez, M. Maneiro, E. Gato, A. Perez, M. Martínez-Guitián, C. Juan, A. Oliver, G. Bou, C. González-Bello,* and A. Beceiro^*

6-Halopyridylmethylidene penicillin-based sulfones efficiently inactivate the natural resistance of Pseudomonas aeruginosa to β-lactam antibiotics

J. Med. Chem. 2021, 64, 6310-6328 (doi: 10.1021/acs.jmedchem.1c00369)

 

E. Lence and C. González-Bello*

Bicyclic Boronate β-Lactamase Inhibitors - The Present Hope Against Deadly Bacterial Pathogens

Adv. Therap. 2021, 4, 2000246 (doi: 10.1002/adtp.2000246).

 

C. Lasarte-Monterrubio, J. C. Vázquez-Ucha, M. Maneiro, J. Arca-Suárez, I. Alonso, P. Guijarro-Sánchez, J. Buynak, G. Bou, C. González-Bello and A. Beceiro

Activity of imipenem, meropenem, cefepime and sulbactam in combination with the β-lactamase inhibitor LN-1-255 against Acinetobacter spp.

Antibiotics 2021, 10, 210 (doi: 10.3390/antibiotics10020210)

 

J. Arca-Suárez, C. Lasarte-Monterrubio, B.-K. Rodiño-Janeiro, G. Cabot, J. C. Vázquez-Ucha, P.  M. Rodríguez-Iglesias, F. Galán-Sánchez, A. Beceiro, C. González-Bello, A. Oliver, and G. Bou

Molecular mechanisms driving in vivo development of OXA-10-mediated resistance to ceftolozane/tazobactam and ceftazidime/avibactam during treatment of extensively drug-resistant Pseudomonas aeruginosa infection

J. Antimicrob. Chemother. 2021, 76, 91-100 (doi:10.1093/jac/dkaa396) (link)

 

2020

I. Andreu, E. Lence, C. González-Bello, C. Mayorga, M. C. Cuquerella, I. Vayá, M. A. Miranda

Protein binding of lapatinib and its N-and O-dealkylated metabolites interrogated by fluorescence, ultrafast spectroscopy and molecular dynamics simulations

Front. Pharmacol. 2020, 11, 574695 (doi: 10.3389/fphar.2020.576495) (link).

 

I. Vayá, I.Andreu, E. Lence, C. González-Bello, M. C. Cuquerella, M. Navarrete-Miguel, D. Roca-Sanjuán, M. A. Miranda

Characterization of the Locally Excited and Charge-transfer States of the Anticancer Drug Lapatinib by Ultrafast Spectroscopy and Computational Studies.

Chem. Eur. J.  2020, 26, 15922-15930  doi 10.1002/chem.202001336 (link).

 

J. Arca-Suárez, J. Carlos Vázquez-Ucha, P. Arturo Fraile-Ribot, E. Lence, G. Cabot, M. Martínez-Guitián, C. Lasarte-Monterrubio, M. Rodríguez-Iglesias, A. Beceiro, C. González-Bello, F. Galán-Sánchez, A. Oliver, and G. Bou

Molecular and biochemical insights into the in vivo evolution of AmpC-mediated resistance to ceftolozane-tazobactam during treatment of a multidrug-resistant Pseudomonas aeruginosa infection

J. Antimicrob. Chemother. 2020, 75, 3209-3217 (doi: 10.1093/jac/dkaa291)

 

E. Lence, M. Maneiro, M. Sanz-Gaitero, M. J. van Raaij, P. Thompson, A. R. Hawkins and C. González-Bello*

Self-Immolation of a Bacterial Dehydratase Enzyme by its Epoxide Product

Chem. Eur. J.  2020, 26, 8035-8044 (doi: 10.1002/chem.202000759; cover 10.1002/chem.202002101)

 

D. Rodríguez, M. Maneiro, J. Vázquez-Ucha, A. Beceiro, and C. González-Bello*

6-Arylmethylidene Penicillin-based Sulfone Inhibitors for Repurposing Antibiotic Efficiency in Priority Pathogens

J. Med. Chem. 2020, 63, 3737-3755 (doi: 10.1021/acs.jmedchem.0c00127) (link)

 

C. González-Bello,* D. Rodríguez, M. Pernas, A. Rodríguez, and E. Colchón

β-Lactamases Inhibitors to Restore the Efficacy of Antibiotics against Superbugs.

J. Med. Chem. 2020, 63, 1859-1881 (special issue Women in Medicinal Chemistry) (link)

 

D. Limones-Herrero, F. Palumbo, V. Vendrell-Criado, I. Andreu,  E. Lence, C. González-Bello, M. A. Miranda, and M. C. Jiménez. Inverstigation of Metabolite-Protein Interactions by Transient Absorpion Spectroscopy and In Silico Methods.

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2020, 226, 117652 (doi: 10.1016/j.saa.2019.117652) (link).

 

2019

O. Molins-Molina, R. Pérez-Ruiz, E. Lence, C. González-Bello, M. A. Miranda, and M. C. Jiménez. Photobinding of Trifusal to Human Serum Albumin Investigated by Fluorescence, Proteomic Analysis and Computational Studies.

Front. Pharmacol. 2019, 10, 1028  (doi: 10.3389/fphar.2019.01028) (link).

 

J. Arca-Suárez, P. Fraile-Ribot, J. Vázquez-Ucha, G. Cabot, M. Martínez-Guitián, E. Lence, C. González-Bello, A. Beceiro, M. Rodríguez-Iglesias, F. Galán-Sánchez, G. Bou, and A. Oliver. Challenging antimicrobial susceptibility and evolution of resistance (OXA-681) during treatment of Pseudomonas aeruginosa ST175 clone long-term nosocomial infection.

Antimicrobial Agents and Chemotherapy 2019, 63, e01110-19 (DOI:10.1128/AAC.01110-19).

J. Vázquez-Ucha, M. Martínez-Guitián, M. Maneiro, K. Conde-Pérez, L. Alvarez-Fraga, G. Torrens, A. Oliver, J. Buynak, R. A. Bonomo, G. Bou, C. González-Bello, M. Poza, and A. Beceiro. Therapeutic efficacy of LN-1-255 in combination with imipenem in severe infection caused by carbapenem-resistant Acinetobacter baumannii.

Antimicrobial Agents and Chemotherapy 2019, 63, e01092-19 (DOI: 10.1128/AAC.01092-19).

M. Maneiro, E. Lence, M. Sanz-Gaitero, J. M. Otero, M. J. van Raaij, P. Thompson, A. R. Hawkins and C. González-Bello*. Hydroxylammonium Derivatives for Selective Active-site Lysine Modification in the Anti-virulence Bacterial Target DHQ1 Enzyme.

Organic Chemistry Frontiers 2019, 6, 3127-3135  (DOI: 10.1039/c9qo00453j) (link).

M. Pernas, B. Blanco, E. Lence, P. Thompson, A. R. Hawkins and C. González-Bello*. Synthesis of Rigidified Shikimic Acid Derivatives by Ring-Closing Metathesis to Imprint Inhibitor Efficacy against Shikimate Kinase.

Organic Chemistry Frontiers 2019, 6, 2514-2528 (DOI: 10.1039/C9QO00562E) (link)

C. González-Bello*. Recently Developed Synthetic Compounds with Anti-infective Activity.

Current Opinion in Pharmacology 2019, 48, 17-23 (doi: 10.1016/j.coph.2019.03.004).

 

O. Molins-Molina, E. Lence, D. Limones-Herrero, C. González-Bello, M. A. Miranda,* M. C. Jiménez*. Identification  of a Common Recognition Center for a Photoactive Non-Steroidal Antiinflammatory Drug in Serum Albumins of Different Species.

Organic Chemistry Frontiers 2019, 6, 99-109. (doi: 10.1039/C8QO01045E).

C. González-Bello.* The Inhibition of Lipid A Biosynthesis - The Antidote Against Superbugs?. 

Advanced Therapeutics 2019, 2, 1800117 (doi: 10.1002/adtp.201800117).

 

2018

R. Pérez-Ruiz, Ó. Molins-Molina, E. Lence, C. González-Bello,* M. A. Miranda,* and M. C. Jiménez*. Photogeneration of Quinone-Methides as Latent Electrophiles for Lysine-Targeting.

Journal of Organic  Chemistry 2018, 83, 13019-13029 (doi: 10.1021/acs.joc.8b01559) (link).

E. Lence, M. W. van der Kamp,* C. González-Bello,* and A. J. Mulholland*. QM/MM Simulations Identify the Determinants of Catalytic Activity Differences Between Type II Dehydroquinase Enzymes.

Organic Biomolecular Chemistry 2018, 16, 4443-4455 (link).

V. Vendrell-Criado, C. González-Bello, M. A. Miranda,* and M. C. Jiménez*. A Combined Photophysical and Computational Study on the Binding of Mycophenolate Mofetil and its Major Metabolite to Transport Proteins.

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2018, 199, 308-314 (link).

C. González-Bello*. 31.5.1.5.12 Synthesis of Phenols and Phenolates from Nonaromatic Precursors (Update 2018).  In Science of Synthesis, Knowledge Updates 2018/3. Bagley, M. C.; Banert, K.; Joule, J. A.; Murai, T.; Ramsden, C. A.; Fuerstner, A.; Carreira, E. M.; Faul, M.; Kobayashi, S.; Koch, G.; Molander, G. A.; Nevado, C.; Trost, B. M.; You, S.-L. Eds. Thieme. Stuttgart. 2018, pp 417-473 (link).

C. González-Bello*. 31.5.1.4.3 Synthesis of Phenols and Phenolates with Retention of the Functional Group (Update 2018). In Science of Synthesis, Knowledge Updates 2018/1. Brøndsted Nielsen, M.; Krause, N.; Rademann, J.; Ramsden, C. A.; Reissig, H.-U.; Fuerstner, A.; Carreira, E. M.; Faul, M.; Koch, G.; Molander, G. A.; Shibasaki, M.; Thomas, E. J.; Trost, B. M. Eds. Thieme. Stuttgart. 2018, pp 245-254 (link).

C. González-Bello*. 31.5.1.3.6 Synthesis of Phenols and Phenolates by Rearrangement (Update 2018). In Science of Synthesis, Knowledge Updates 2018/1. Brøndsted Nielsen, M.; Krause, N.; Rademann, J.; Ramsden, C. A.; Reissig, H.-U.; Fuerstner, A.; Carreira, E. M.; Faul, M.; Koch, G.; Molander, G. A.; Shibasaki, M.; Thomas, E. J.; Trost, B. M. Eds. Thieme. Stuttgart. 2018, pp 239-244 (link).

 

C. González-Bello*. 31.5.1.2.7 Synthesis of Phenols and Phenolates by Elimination (Update 2018). In Science of Synthesis, Knowledge Updates 2018/1. Brøndsted Nielsen, M.; Krause, N.; Rademann, J.; Ramsden, C. A.; Reissig, H.-U.; Fuerstner, A.; Carreira, E. M.; Faul, M.; Koch, G.; Molander, G. A.; Shibasaki, M.; Thomas, E. J.; Trost, B. M. Eds. Thieme. Stuttgart. 2018, pp 233-238 (link).

C. González-Bello*. 31.5.1.1.18 Synthesis of Phenols and Phenolates by Substitution (Update 2018). In Science of Synthesis, Knowledge Updates 2018/1. Brøndsted Nielsen, M.; Krause, N.; Rademann, J.; Ramsden, C. A.; Reissig, H.-U.; Fuerstner, A.; Carreira, E. M.; Faul, M.; Koch, G.; Molander, G. A.; Shibasaki, M.; Thomas, E. J.; Trost, B. M. Eds. Thieme. Stuttgart. 2018, pp 211-232 (link).

 

2017

C. González-Bello*. Antibiotic Adjuvants - A Strategy to Unlock Bacterial Resistance to Antibiotics. Bioorganic & Medicinal Chemistry Letters  2017, 27, 4221-4228. Link

 

R. Pérez-Ruiz, E. Lence, I. Andreu, D. Limones-Herrero, C. González-Bello, M. A. Miranda* and M. C. Jiménez*. A Novel Pathway of Protein Haptenation by ß-Lactams.

Chemistry, European Journal  2017, 23, 13986-13994. Link

 

J.C. Vázquez-Ucha, M. Maneiro, M. Martínez-Guitián, J. Buynak, C.R. Bethel, R.A. Bonomo, G. Bou, C. González-Bello and A. Beceiro. Activity of the β-Lactamase inhibitor LN-1-255 against carbapenem-hydrolyzing class D β-lactamases from Acinetobacter baumannii.

Antimicrobial Agents and Chemotherapy 2017, 61, e01172-17. Link

 

A. Peón, A. Robles, B. Blanco, M. Convertino, P. Thompson, A. R. Hawkins, A. Caflisch* and C. González-Bello*. Reducing the Flexibility of Type II Dehydroquinase Enzyme for Inhibition - A Fragment-Based Approach and Molecular Dynamics Simulation Study.

ChemMedChem 2017, 12, 1512-1524. Link

 

D. Limones-Herrero, R. Pérez-Ruiz, E. Lence, C. González-Bello, M. A. Miranda,* and M. C. Jiménez*. Mapping a protein recognition centre with chiral photoactive ligands. An integrated approach combining photophysics, reactivity, proteomics and molecular dynamic simulation studies.

Chemical Science 2017, 8, 2621-2628. Link.

 

2016

V. Prado, E. Lence, P. Thompson, A. R. Hawkins and C. González-Bello*. Freezing the Dynamic Gap for Selectivity - Motion-based Design of Inhibitors of the Shikimate Kinase Enzyme.

Chemistry, European Journal 2016, 22, 17988-18000. Link

J. Sanmartín-Matalobos,* C. González-Bello, L. Briones-Miguéns, M. Fondo and A. M. García-Deibe. Degradation of the active species in the catalytic system Pd(OAc)2/NEt3.

RSC Advances 2016, 6, 103088-103094. Link

C. González-Bello*. Targeting the Motion of Shikimate Kinase - Opportunities for Antibiotic Drug Development. Medicinal Chemistry 2016, 6(10) 49 (doi: 10.4172/2161-0444.C1.027).

 

V. Prado, E. Lence, M. Maneiro, J. C. Vázquez-Ucha, A. Beceiro, P. Thompson, A. R. Hawkins and C. González-Bello*. Targeting the Motion of Shikimate Kinase: Development of Competitive Inhibitors that Stabilize an Inactive Open Conformation of the Enzyme.

Journal of Medicinal Chemistry 2016, 59, 5471-5487. Link

 

J. A. Vallejo, M. Martínez-Guitián, J. C. Vázquez-Ucha, C. González-Bello, M. Poza, J. D. Buynak, C. R. Bethel, R. A. Bonomo, G. Bou and A. Beceiro*. LN-1-255, a Penicillanic Acid Sulfone Able to Inhibit the Class D Carbapemenease OXA-48.

Journal of Antimicrobial Chemotherapy 2016, 7, 2171-2180. Link

 

V. Prado, E. Lence, J. A. Vallejo, A. Beceiro, P. Thompson, A. R. Hawkins and C. González-Bello*. Study of the Phosphoryl-Transfer Mechanism of Shikimate Kinase by NMR Spectroscopy.

Chemistry, European Journal  2016, 22, 2758-2768. Link

 

C. González-Bello*. Designing Irreversible Inhibitors - Worth the Effort?.

ChemMedChem 2016, 11, 22-30. Link

C. González-Bello*. Inhibition of Shikimate Kinase and Type II Dehydroquinase for Antibiotic Discovery: Structure-Based Design and Simulation Studies.

Current Topics in Medicinal Chemistry 2016, 16, 960-977. Link

 

2015

C. González-Bello*. Specific Chemical Modification of Bacterial Type I Dehydroquinase – Opportunities for Drug Discovery.

Future Medicinal Chemistry 2015, 7, 2371-2383.

C. González-Bello*. Covalent Inhibition of Bacterial Type I Dehydroquinase - Opportunities for anti-virulence therapies.

Medicinal Chemistry 2015, 5(10) 22 (doi: 10.4172/2161-0444.C1.014).

C. González-Bello,* L.Tizón, E. Lence, J. M. Otero, M. J. van Raaij, M. Martinez-Guitian, A. Beceiro, P.  Thompson, and A. R. Hawkins. Chemical Modification of a Dehydratase Enzyme Involved in Bacterial Virulence by an Ammonium Derivative: Evidence of its Active Site Covalent Adduct.

J. Am. Chem. Soc. 2015, 137, 9333-9343.

M. Fondo,* J. Doejo, A. M. García-Deibe, J. Sanmartín, C. González-Bello and R. Vicente. Hydrolysis of imidazolidine ligands mediated by CuII: mononuclear, tetranuclear and 1D CuII-amine complexes.

Polyhedron 2015, 100, 49-58.

C. Costas, V. Lopez-Puente, G. Bodelon*, C. González-Bello, J. Perez-Juste, I. Pastoriza-Santos and L. M. Liz-Marzan*. Using Surface Enhanced Raman Scattering to Analyze the Interactions of Protein Receptors with Bacterial Quorum Sensing Modulators.

ACS Nano 2015, 9, 5567-5576.

L. Tizón, M. Maneiro, A. Peón, J. M. Otero, E. Lence, S. Poza, M. J. van Raaij, P. Thompson, A. R. Hawkins and C. González-Bello*. Irreversible Covalent Modification of Type I Dehydroquinase by a Stable Schiff Base.

Organic Biomolecular Chemistry 2015, 13, 706-716.

 

2014

 M. Maneiro, A. Peón, E. Lence, J. M. Otero, M. J. van Raaij, P. Thompson, A. R. Hawkins and C. González-Bello*. Insights into Substrate Binding and Catalysis in Bacterial Type I Dehydroquinase.

Biochemical Journal 2014, 462, 415-424.

C. Coderch, E. Lence, A. Peón, H. Lamb, A R. Hawkins, F. Gago* and C. González-Bello*. Mechanistic insight into the reaction catalysed by bacterial Type II dehydroquinases.

Biochemical Journal 2014, 458, 547-557.

B. Blanco, A. Sedes, A. Peón, J. M. Otero, M. J. van Raaij, P. Thompson, A. R. Hawkins and C. González-Bello*. Exploring the Water-binding Pocket of the Type II Dehydroquinase Enzyme in the Structure-based Design of Inhibitors.

Journal of Medicinal Chemistry 2014, 57, 3494-3510.

J. Sanmartín-Matalobos*, A. M. García-Deibe, L. Briones-Miguéns, C. González-Bello, C. Portela-García and M. Fondo. Dual Role of 2-tosylaminomethylaniline as Ligand and Nucleophile in the Copper-mediated Oxidation of Methanol.

Dalton Transations 2014, 43, 722-728.

 

2013

B. Blanco, V. Prado, E. Lence, J. M. Otero, C. Garcia-Doval, M. J. van Raaij, A. L. Llamas-Saiz, H. Lamb, A. R. Hawkins, and C. González-Bello*. Mycobacterium tuberculosis Shikimate Kinase Inhibitors: Design and Simulation Studies of the Catalytic Turnover.

Journal of American Chemical Society 2013, 135, 12366-12376.

A. Peón, C. Coderch, F. Gago and C. González-Bello*. Comparative Binding Energy (COMBINE) Analysis for Understanding the Binding Determinants of Type II Dehydroquinase Inhibitors.

ChemMedChem 2013, 8, 740-747.

 

E. Lence, L. Tizón, J. M. Otero, A. Peón, V. F. V. Prazeres, A. L. Llamas, G. C. Fox, M. J. van Raaij, H. Lamb, A. R. Hawkins and C. González-Bello*. Mechanistic Basis of the Inhibition of Type II Dehydroquinase by (2S)- and (2R)-2-Benzyl-3-dehydroquinic Acids.

ACS Chemical Biology 2013, 8, 568-577 (cover).

 

J. Sanmartín-Matalobos,* A. M. García-Deibe, L. Briones-Miguéns, E. Lence, C. González-Bello*, C. Portela-García and M. Fondo.
Serendipitous formation of 3-tosyl-1,2,3,4-tetrahydroquinazoline.

New J. Chemistry 2013, 37, 3043-3049.

 

L. Briones-Miguéns, A. M. García-Deibe, M. Fondo, J. Sanmartín-Matalobos, E. Lence and C. González-Bello. A convenient Pd-mediated oxidation of 4-methylbenzyl alcohol. Proceedings of the 17th International Electronic Conference on Synthetic Organic Chemistry, 1-30 November 2013; Sciforum Electronic Conference Serie 2013, 17, a012; doi:10.3390/ecsoc-17-a012.

C. Portela-García, J. Sanmartín-Matalobos, A. M. García-Deibe, M. Fondo, E. Lence and C. González-Bello. Mechanistic insights into a Zn-assisted ring-chain tautomerism process involving a 1,2,3,4-tetrahydroquinazoline and a Schiff base. Proceedings of the 17th International Electronic Conference on Synthetic Organic Chemistry, 1-30 November 2013; Sciforum Electronic Conference Serie 2013, 17, e008; doi:10.3390/ecsoc-17-e008.

J. Sanmartín-Matalobos, L. Briones-Miguéns, C. Portela-García, A. M. García-Deibe, M. Fondo and C. González-Bello. Copper-mediated aerobic synthesis of 3-tosyl-1,2,3,4-tetrahydroquinazoline from 2-tosylaminomethylaniline and methanol. Proceedings of the 17th International Electronic Conference on Synthetic Organic Chemistry, 1-30 November 2013; Sciforum Electronic Conference Serie 2013, 17, a003; doi:10.3390/ecsoc-17-a003.

L. Briones-Miguéns, C. Portela-García, A. M. García-Deibe, M. Fondo, J. Sanmartín-Matalobos, E. Lence and C. González-Bello. Computational studies on the palladium-mediated oxidation of methanol to formaldehyde. Proceedings of the 17th International Electronic Conference on Synthetic Organic Chemistry, 1-30 November 2013; Sciforum Electronic Conference Serie 2013, 17, e010; doi:10.3390/ecsoc-17-e010.

 

2012

J. Sanmartín-Matalobos*, C. Portela-García, L. Martínez-Rodríguez, C.González-Bello*, E. Lence, A. M. García-Deibe and M. Fondo. Structural Variety of Zinc and Copper Complexes Based on a 2,3 Disubstituted 1,2,3,4-Tetrahydroquinazoline Ligand.

Dalton Transations 2012, 41, 6998-7004.

B. Blanco, A. Sedes, A. Peón, H. Lamb, A. R. Hawkins, L. Castedo and C. González-Bello*. Synthesis of 3-Alkyl Enol Mimics Inhibitors of Type II Dehydroquinase: Factors Influencing Their Inhibition Potency.

Organic Biomolecular Chemistry 2012, 10, 3662-3676 (cover).

A. M. García-Deibe, J.Sanmartín-Matalobos*, C. González-Bello, E. Lence, C. Portela-García, L. Martínez-Rodríguez and M. Fondo.Metal-assisted Ring-opening/closing Process of a Chiral tetrahydroquinazoline.

Inorganic Chemistry 2012, 51, 1278-1293.

 

2011

C. González-Bello*. Author profile.

ChemMedChem 2011, 6, 591.

 

L. Tizón, J. M. Otero, V. F. V. Prazeres, A. L. Llamas-Saiz, G. C. Fox, M. J. van Raaij, H. Lamb, A. R. Hawkins, J. A. Ainsa, L. Castedo and C. González-Bello*. A Prodrug Approach for Improving Anti-tuberculosis Activity of Potent Mycobacterium tuberculosis Type II Dehydroquinase Inhibitors.

Journal of Medicinal Chemistry 2011, 54, 6063-6084 (cover).

 

S. Paz, L. Tizón, J. M. Otero, A. L. Llamas-Saiz, G. C. Fox, M. J. van Raaij, H. Lamb, A. R. Hawkins, A. J. Lapthorn, L. Castedo and C. González-Bello*. Tetrahydrobenzothiophene Derivatives as Inhibitors of type II Dehydroquinase.

ChemMedChem 2011, 6, 266-272.

C. González-Bello and L. Castedo. Six-Membered Heterocycles: Pyridine. In Modern Heterocyclic Chemistry. J. Álvarez-Builla, J. J. Vaquero and J. Barluenga Eds. Willey-VCH. Weinheim. ISBN: 978-3-527-33201-4. 2011, Vol 3, pp 1431-1525.

L. Castedo, C. González, E. Guitián, E. Guitián and G. Nikonov. Benzenediazonium-2-carboxylate. In e-EROS Encyclopedia of Reagents for Organic Synthesis, Second Edition. Leo Paquette, David Crich, Philip L. Fuchs, and Gary A. Molander Eds. John Wiley & Sons. Chichester. ISBN: 978-0-470-84289-8. 2011, DOI: 10.1002/047084289X.rb006.pub2.

 

2010

V. F. V. Prazeres, L. Tizón, J. M. Otero, P. Guardado-Calvo, A. L. Llamas-Saiz, M. J. van Raaij, L. Castedo and C. González-Bello*. Competitive Inhibitors of Helicobacter pylori Type II Dehydroquinase. Structural Details of the Role of The Aromatic Moieties Interactions with Essential Residues.

Drug of the Future 2010, 35 (supl A), 190-191.

B. Blanco, A. Sedes, C. Sánchez-Sixto, L. Castedo and C. González-Bello*. Enol Mimics with a Flexible Side Chain as Inhibitors of Mycobacterium tuberculosis Dehydroquinase.

Drug of the Future 2010, 35 (supl A), 190.

A. Peón, L. Tizón, V. F. V. Prazeres, L. Castedo and C. González-Bello*. Steady-State Fluorescence and Molecular Dynamic Studies on the Inhibition of Type II Dehydroquinase by (2R)-3-Benzyl-3-Dehydroquinic Acids.

Drug of the Future 2010, 35 (supl A), 175-176.

V. B. C. Figueira, A. G. Esqué, R. Varala, C. González-Bello, S. Prabhakar and A. M. Lobo*. Functional desymmetrization of 1,3-dioximes for the obtention of 1,2,3-heteo trisubstituted carbocycles.

Tetrahedron Letters 2010, 51, 2029-2031.

 

V. F. V. Prazeres, L. Tizón, J. M. Otero, P. Guardado-Calvo, A. L. Llamas-Saiz, M. J. van Raaij, L. Castedo, H. Lamb, A. R. Hawkins and C. González-Bello*. Synthesis and Biological Evaluation of New Nanomolar Competitive Inhibitors of Helicobacter pylori Type II Dehydroquinase. Structural Details of the Role of the Aromatic Moieties with Essential Residues.

J. Med. Chem. 2010, 53, 191-200.

 

V. D. B. Bonifácio, C. González-Bello, H. S. Rzepa, S. Prabhakar and A. M. Lobo*. Chiral Aziridination of Olefins using a Chiral Sulfinamide as the Nitrogen Source.

Synlett 2010, 145-149.

 

A. Peón, J. M. Otero, L. Tizón, V. F. V. Prazeres, A. L. Llamas-Saiz, G. C. Fox, M. J. van Raaij, H. Lamb, A. R. Hawkins, F. Gago L. Castedo and C. González-Bello*. Understanding the Key Factors that Control the Inhibition of Type 2 Dehydroquinase by (2R)-2-Benzyl-3-dehydroquinic acids.

ChemMedChem 2010, 5, 1726-1733.

 

1990-2009

V. F. V. Prazeres, L. Castedo, H. Lamb, A. R. Hawkins and C. González-Bello*. 2-Substituted-3-Dehydroquinic Acids as Potent Competitive Inhibitors of Type II Dehydroquinase.

ChemMedChem 2009, 4, 1980-1984.

E. Lence, L. Castedo and C. González-Bello*. A selective Resin for trans-Diequatorial-1,2-diols.

Tetrahedron Letters 2009, 50, 1795-1798.

V. F. V. Prazeres, C. Sánchez-Sixto, L. Castedo, S. W. Shuh, H. Lamb, A. R. Hawkins, F. J. Cañada, J. Jiménez-Barbero and C. González-Bello*. Helicobacter pylori Dehydroquinase Competitive Inhibitors: Synthesis, Biological Evaluation and NMR Studies.

ChemMedChem 2008, 3, 756-770.

V. F. V. Prazeres, L. Castedo and C. González-Bello*.Stereoselective Synthesis of Novel Cyclic gamma-Amino acids and Triazole Derivatives.

Eur. J. Org. Chem. 2008, 3991-4003.

C. Sánchez-Sixto, V. F. V. Prazeres, L. Castedo and C. González-Bello*. Nanomolar Inhibitors of Helicobacter pylori Dehydroquinase with Potential Antimicrobial Activity.

Drugs of the Future 2008, 33 (Supl. A), 177-178.

E. Lence, L. Castedo and C. González-Bello*. The conformational rigidity of butane-1,2-diacetals as a powerful synthetic tool.

Chem. Soc. Rev. 2008, 37, 1756-1808.

C. González-Bello*. The Medicinal Chemistry of Anti-Infectious Agents.

Curr. Top. Med. Chem. 2008, 8, 532.

 

 V. F. V. Prazeres, C. Sánchez-Sixto, L. Castedo, H. Lamb, A. R. Hawkins, A. Riboldi-Tunnicliffe, J. R. Coggins, A. J. Lapthorn and C. González-Bello*. Nanomolar Competitive Inhibitors of Mycobacterium tuberculosis and Streptomyces coelicolor Type II Dehydroquinase.

ChemMedChem 2007, 2, 194-207 (cover).

C. González-Bello* and L. Castedo. Progress in Type II Dehydroquinase Inhibitors: from Concept to Practice.

Med. Res. Rev. 2007, 27, 177-208 (cover).

C. González-Bello and L. Castedo. 31.5.1 Product Subclass 1: Monohydric Phenols and Corresponding Phenolates. 31.5.1.1 Synthesis by Substitution. . In Science of Synthesis, Houben-Weyl Methods of Molecular Transformations, Volumen 31a: Compounds with Two Carbon-Heteroatom Bonds: Arene-X (X= Hal, O, S, Se, Te). Chris Ramsden Ed. Thieme. Stuttgart. ISBN: 978-3-13-118831-1. 2007, Vol 31a, pp 275-304.

 

C. González-Bello and L. Castedo. 31.5.1 Product Subclass 1: Monohydric Phenols and Corresponding Phenolates. 31.5.1.2 Synthesis by Elimination. In Science of Synthesis, Houben-Weyl Methods of Molecular Transformations, Volumen 31a: Compounds with Two Carbon-Heteroatom Bonds: Arene-X (X= Hal, O, S, Se, Te). Chris Ramsden Ed. Thieme. Stuttgart. ISBN: 978-3-13-118831-1. 2007, Vol 31a, pp 305-318.

 

C. González-Bello and L. Castedo. 31.5.1 Product Subclass 1: Monohydric Phenols and Corresponding Phenolates. 31.5.1.3 Synthesis by Rearrangement. In Science of Synthesis, Houben-Weyl Methods of Molecular Transformations, Volumen 31a: Compounds with Two Carbon-Heteroatom Bonds: Arene-X (X= Hal, O, S, Se, Te). Chris Ramsden Ed. Thieme. Stuttgart. ISBN: 978-3-13-118831-1. 2007, Vol 31a, pp 319-330.

C. González-Bello and L. Castedo. 31.5.1 Product Subclass 1: Monohydric Phenols and Corresponding Phenolates. 31.5.1.4 Synthesis with Retention of the Functional Group.  In Science of Synthesis, Houben-Weyl Methods of Molecular Transformations, Volumen 31a: Compounds with Two Carbon-Heteroatom Bonds: Arene-X (X= Hal, O, S, Se, Te). Chris Ramsden Ed. Thieme. Stuttgart. ISBN: 978-3-13-118831-1. 2007, Vol 31a, pp 331-336.

V. F. V. Prazeres, C. Sánchez-Sixto, L. Castedo, A. Canales, F. J. Cañada, J. Jiménez-Barbero, H. Lamb, A. R. Hawkins and C. González-Bello*. Determination of the Bound Conformation of a Competitive Nanomolar Inhibitor of Mycobacterium tuberculosis Type II Dehydroquinase by NMR Spectroscopy.

ChemMedChem 2006, 1, 990-996.

C. González-Bello*, L. Castedo and F. J. Cañada. Synthesis of Spiro Carba-sugars by Ring-Closing Metathesis.

Eur. J. Org. Chem. 2006, 1002-1011.

 

C. Sánchez-Sixto, V. F. V. Prazeres, L. Castedo, H. Lamb, A. R. Hawkins and C. González-Bello*.Structure-Based Design, Synthesis and Biological Evaluation of Inhibitors of Mycobacterium tuberculosis Type II Dehydroquinase.

Journal of Medicinal Chemistry 2005, 48, 4871-4881.

M. Carballido, L. Castedo and C. González-Bello*. Synthesis of Amino Carba-sugars and Conformationally Restricted Polyhydroxy-gamma-amino Acids from (−)-Quinic Acid.

Eur. J. Org. Chem. 2004, 3663-3668.

 

C.González-Bello*, E. Lence, M. D. Toscano, L. Castedo, J. R. Coggins and C. Abell. Parallel Solid-Phase Synthesis and Evaluation of Inhibitors of Streptomyces coelicolor Type II Dehydroquinase.

Journal of Medicinal Chemistry  2003, 46, 5735-5744.

M. D. Toscano, M. Frederickson, D. P. Evans, John R. Coggins, C. Abell* and C. González-Bello. Design, Synthesis and Evaluation of Bifunctional Inhibitors of Type II Dehydroquinase.

Org. Biomol. Chem. 2003, 1, 2075-2083.

 

C. González-Bello*, M. Carballido and L. Castedo. Synthesis of Polyhydroxycyclohexanes from (-)-Quinic Acid.

J. Org. Chem. 2003, 68, 2248-2255.

C. González-Bello and L. Castedo. Synthesis of Phenols. In The Chemistry of Phenols Serie Patai; The Chemistry of Functional Groups. Zvi Rappoport Ed. John Wiley & Sons. Chichester. ISBN 978-0-471-49737-0. 2003, Vol 1, pp 395-489.

E. Lence, L. Castedo and C. González-Bello*. Mild, Aprotic Synthesis of 1,2-Diacetals.

Tetrahedron Letters 2002, 43, 7917-7918.

M. Carballido, L. Castedo and C. González-Bello*. Synthesis of Carba-sugars from (-)-Quinic Acid.

Tetrahedron Letters 2001, 42, 3973-3976.

 

L. Castedo, C. González and E. Guitián. Benzenediazonium-2-carboxylate. e-EROS Encyclopedia of Reagents for Organic Synthesis. L Leo Paquette, David Crich, Philip L. Fuchs, and Gary A. Molander Eds. John Wiley & Sons. Chichester. ISBN 978-0-470-84289-8. 2001, DOI: 10.1002/047084289X.rb006

E. J. Parker, C. González-Bello, J. R. Coggins and C. Abell. Mechanistic Studies on Type I and Type II Dehydroquinase with (6R)- and (6S)-6-Fluoro-3-dehydroquinic Acids.

Bioorg. Med. Chem. Lett. 2000, 10, 231-234.

C. González-Bello, J. M. Harris, M. K. Manthey, J. R. Coggins and C. Abell. Irreversible Inhibition of Type I Dehydroquinase by Substrates for Type II Dehydroquinase.

Bioorg. Med. Chem. Lett. 2000, 10, 405-408.

C. González-Bello, J. R. Coggins, A. R. Hawkins and C. Abell*. Synthesis of 4-Deoxyquinic, 4-Deoxyshikimic and 4-Deoxy-3-dehydroshikimic Acids.

J. Chem. Soc., Perkin Trans. 1 1999, 849-854.

C. González-Bello, Enrique Guitián* and Luis Castedo. Synthesis of Phenanthridones, Quinolinequinones and 7-Azasteroids.

Tetrahedron 1999, 55, 5195-5206.

 

C. González-Bello, M. K. Manthey, J. M. Harris, A. R. Hawkins, J. R. Coggins and C. Abell*. Synthesis of 2-Bromo- and 2-Fluoro-3-dehydroshikimic acids and 2-Bromo- and 2-Fluoroshikimic Acids using Synthetic and Enzymatic Approaches.

J. Org. Chem. 1998, 63, 1591-1597.

 

C. González-Bello, C. Abell and F. J. Leeper*. Synthesis of Tetrahydroquinolines, Hexahydrobenzoindolizidines and an Aryl Phosphate Linker for the Generation of Catalytic Antibodies.

J. Chem. Soc., Perkin Trans. 1 1997, 1017-1024.

 

M. K. Manthey, C. González-Bello and C. Abell*.Synthesis of (2R)-2-Bromodehydroquinic Acid and (2R)-2-Fluorodehydroquinic Acid.

J. Chem. Soc., Perkin Trans. 1 1997, 625-628.

 

Johana M. Harris, C. González-Bello, C. Kleanthous, A. R. Hawkins, J. R. Coggins and C. Abell*. Evidence from Kinetic Isotope Studies for an Enolate Intermediate in the Mechanism of Type II Dehydroquinases.

Biochemical Journal 1996, 319, 333-336.

 

C. González, E. Guitián* and L. Castedo. A New Intramolecular Aryne Cycloaddition Approach to Lycorines.

Tetrahedron Letters 1996, 37, 405-406.

C. González, D. Pérez, E. Guitián* and L. Castedo. Synthesis of Lycorines by Intramolecular Aryne Cycloadditions.

J. Org. Chem. 1995, 60, 6318-6326.

 

L. Castedo, C. González and E. Guitián. Carboxybenzenediazonium hydroxide Inner Salt. Encyclopedia of Reagents for Organic Synthesis. Leo Paquette Ed. John Wiley & Sons. Chichester. ISBN 978-0-471-93623-7. 1995, pp. 244-247.

K. Vanhessche, C. González and M. Vandewalle*.Total Synthesis of (-)-Neplanocin A from L-Ribulose.

Synlett 1991, 921-922.

B. Gómez, C. González, D. Pérez, E. Guitián* and L. Castedo. New Methods of Synthesis of Amaryllidaceae Alkaloids.

Planta Medica 1990, 56, 516-517.